Signature Cells: High-potency cells for more effective treatment.
Case Studies and Reports
Scientific References, Citations and Articles
Chronic Pain
• Looi, Qi Hao and Eng, Sue Ping and Liau, Ling Ling and Tor, Yin Sim and Mohd, Yazid Bajuri, and Ng, Min Hwei and Law, Jia Xian. Mesenchymal stem cell therapy for sports injuries - from research to clinical practice. Sains Malaysiana;2020.49(4):825-38. Available from: http://journalarticle.ukm.my/15354/
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• Trebinjac S, Gharairi M. Mesenchymal Stem Cells for Treatment of Tendon and Ligament Injuries-clinical Evidence. Med Arch. 2020 Oct;74(5):387-390. doi: 10.5455/medarh.2020.74.387-390.
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• Kader N, Asopa V, Baryeh K, Sochart D, Maffulli N, Kader D. Cell-based therapy in soft tissue sports injuries of the knee: a systematic review. Expert Opin Biol Ther. 2021 Aug;21(8):1035-1047. doi: 10.1080/14712598.2021.1872538.
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• Baryeh K, Asopa V, Kader N, Caplan N, Maffulli N, Kader D. Cell-based therapies for the treatment of sports injuries of the upper limb. Expert Opinion on Biological Therapy. 2021;21(12):1561-74. DOI: 10.1080/14712598.2021.1928630
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• Stewart C. Stem cells and regenerative medicine in sport science. Emerg Top Life Sci. 2021;5(4): 563–73. doi: https://doi.org/10.1042/ETLS20210014
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• Song Y, Zhang J, Xu H, Lin Z, Chang H, Liu W, Kong L. Mesenchymal stem cells in knee osteoarthritis treatment: A systematic review and meta-analysis. J Orthop Translat. 2020 Apr 27;24:121-130. doi: 10.1016/j.jot.2020.03.015.
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• Cho WS, Chung SG, Kim W, Jo CH, Lee SU, Lee SY. Mesenchymal Stem Cells Use in the Treatment of Tendon Disorders: A Systematic Review and Meta-Analysis of Prospective Clinical Studies. Ann Rehabil Med. 2021 Aug;45(4):274-283. doi: 10.5535/arm.21078.
Autoimmune
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• Meng, M., Liu, Y., Wang, W., Wei, C., Liu, F., Du, Z., Xie, Y., Tang, W., Hou, Z., & Li, Q. Umbilical cord mesenchymal stem cell transplantation in the treatment of multiple sclerosis. American journal of translational research. 2018;10(1):212–23. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5801359/
• Riordan, N. H., Morales, I., Fernández, G., Allen, N., Fearnot, N. E., Leckrone, M. E., et al. Clinical feasibility of umbilical cord tissue-derived mesenchymal stem cells in the treatment of multiple sclerosis. Journal of translational medicine.2018;16(1):57. Available from: https://doi.org/10.1186/s12967-018-1433-7
• Barczewska M, Grudniak M, Maksymowicz S, Siwek T, Oldak T, Jezierska-Wozniak K, et al. Safety of intrathecal injection of Wharton’s jelly derived mesenchymal stem cells in amyotrophic lateral sclerosis therapy. Neural Regen Res. 2019;14(2):313–8. https://pubmed.ncbi.nlm.nih.gov/30531015/
• Leyendecker A Jr, Pinheiro CCG, Amano MT, Bueno DF. The Use of Human Mesenchymal Stem Cells as Therapeutic Agents for the in vivo Treatment of Immune-Related Diseases: A Systematic Review. Front Immunol. 2018 Sep 11;9:2056. doi: 10.3389/fimmu.2018.02056.
• Cui, J., Jin, L., Ding, M. et al. Efficacy and safety of mesenchymal stem cells in the treatment of systemic sclerosis: a systematic review and meta-analysis. Stem Cell Res Ther 13, 118 (2022). https://doi.org/10.1186/s13287-022-02786-3
• Reyes-Martínez V, Londoño J, Ávila-Portillo LM, Rueda JC, Padilla-Ortiz DM, Salgado D, et al . Mesenchymal stromal cells represent a therapeutic option for systemic sclerosis patients. Rev.Colomb.Reumatol. 2020;27(Suppl 1):126-34. Available from: https://doi.org/10.1016/j.rcreu.2020.02.007.
Neurological Conditions
• Földes, A., Kádár, K., Kerémi, B., Zsembery, Á., Gyires, K., S Zádori, Z., & Varga, G. (2016). Mesenchymal Stem Cells of Dental Origin-Their Potential for Antiinflammatory and Regenerative Actions in Brain and Gut Damage. Current neuropharmacology, 14(8), 914–934. https://doi.org/10.2174/1570159x14666160121115210
• Zheng H, Zhang B, Chhatbar PY, Dong Y, Alawieh A, Lowe F, Hu X, Feng W. Mesenchymal Stem Cell Therapy in Stroke: A Systematic Review of Literature in Pre-Clinical and Clinical Research. Cell Transplant. 2018 Dec;27(12):1723-1730. doi: 10.1177/0963689718806846.
• Schepici G, Silvestro S, Bramanti P, Mazzon E. Traumatic Brain Injury and Stem Cells: An Overview of Clinical Trials, the Current Treatments and Future Therapeutic Approaches. Medicina (Kaunas). 2020 Mar 19;56(3):137. doi: 10.3390/medicina56030137. PMID: 32204311; PMCID: PMC7143935.
• Rahman MM, Islam MR, Islam MT, Harun-Or-Rashid M, Islam M, Abdullah S, et al. Stem Cell Transplantation Therapy and Neurological Disorders: Current Status and Future Perspectives. Biology. 2022; 11(1):147. https://doi.org/10.3390/biology11010147
• Kassis I, Petrou P, Vaknin-Dembinsky A, Karussis D. Mesenchymal stem cells in neurological diseases. Clin. Invest. 2013;3(2):173–89. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202001/
• Chung JW, Chang WH, Bang OY, Moon GJ, Kim SJ, Kim SK, Lee JS, Sohn SI, Kim YH; STARTING-2 Collaborators. Efficacy and Safety of Intravenous Mesenchymal Stem Cells for Ischemic Stroke. Neurology. 2021 Feb 16;96(7):e1012-e1023. Available from: https://doi.org/10.1212/WNL.0000000000011440
• Sun, J. M., Dawson, G., Franz, L., Howard, J., McLaughlin, C., Kistler, B., Waters-Pick, B., Meadows, N., Troy, J., & Kurtzberg, J. Infusion of human umbilical cord tissue mesenchymal stromal cells in children with autism spectrum disorder. Stem cells translational medicine.2020:9(10):1137–1146. Available from: https://doi.org/10.1002/sctm.19-0434
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