Signature Cells: High-potency cells for more effective treatment
High-potency cells from umbilical cords and a proprietary protocol to select and culture highly potent cells offers advanced treatments that meet strict criteria for:
High levels of anti-inflammatory properties
Best potential to modulate your immune system
More potential to stimulate healing
Research shows that these cells are highly effective at promoting healing, reducing inflammation, and repairing damaged tissues.
What are MSC cells?
Because millions of cells in our bodies die and become damaged each day, they need to be constantly replaced. This is the body’s natural repair process, which is how injuries heal and how we recover from diseases.
All cells — regardless of function — are created from one special type of cell — a stem cell. Through a process called differentiation, a stem cell divides into two cells. That second “daughter” cell can be another stem cell or other type of new cell.
Normally the body has enough stem cells to support the need to generate new cells. But there are various reasons why there may not be enough stem cells available to replace cells needed to promote healing and fight diseases. Cell therapy has attracted the interest of the scientific community because new research and studies show that treatment with various types of cells can help supplement the body to use its own stem cells to improve the regenerative process and promote healing.
Some of these studies show that one specific type of cell — mesenchymal stem cells (also known as medicinal signaling cells) — offer more healing potential because these cells:
Exhibit exceptional regenerative properties
Demonstrate highly effective anti-inflammatory properties – reducing levels of pro-inflammatory cytokines and increasing levels of anti-inflammatory cytokines
Release growth factors that the body can use to promote healing
How cell therapy works
All cells — regardless of function — are created from stem cells that have the potential to differentiate into specific cells in various organs or tissues through a natural development of growth process.
Indeed, stem cells work as part of the body’s natural “repair team” to replace the many different types of cells in the various structures, organs, and tissues.
If you burn your skin, your body turns stem cells into new skin cells.
If you’re fighting an infection, your body turns stem cells into new immune cells.
And if the cartilage tissue in a joint deteriorates, your body turns stem cells into new cartilage cells.
Types of stem cells:
There are several different sources of stem cells that have been studied for use in treatment. These include:
Adult or somatic stem cells: Extracted from the adipose (fatty) tissue or bone marrow from a patient or another compatible donor, these stem cells have been used to treat patients. But because these cells are older, they usually do not provide as much healing potential, nor help ease chronic inflammation.
Embryonic stem cells: Although stem cells from embryos are very young and have significant potential to differentiate effectively, ethical issues surrounding the use of embryos for medical procedures prevents the use of these cells in most countries.
Reprogrammed IPs cells: In some cases, adult stem cells can be modified to offer high potency similar to embryonic cells. Although this approach avoids the ethical conflicts of using actual embryos, genetically modifying cells tends to make them too unstable to use for treatment.
Perinatal cells: These cells come from tissue that’s usually discarded after birth, including the placenta, amniotic fluids, and umbilical cord. Because these cells are young, they can be highly potent to promote healing and control inflammation, but because they are the byproduct of an actual birth, use of these cells does not create any ethical concerns.
At BioXcellerator, we use a special type of perinatal cell that comes from the Wharton’s Jelly in umbilical cords donated for treatment purposes. That’s because research shows that the cells in this tissue can be isolated and expanded into infusions of high-potency cells that can improve the potential for successful treatment and offer high anti-inflammatory properties.
Cell therapy using allogeneic Wharton’s jelly mesenchymal stem cells (WJ-MSC) derived from umbilical cords represents an exciting frontier in the science of medicine. Although these cells do not replace damaged cells in the body, research shows that these cells:
Signal other cells throughout the body by producing various chemicals that promote healing more effectively than adult stem cells
Can be cultured and expanded in a laboratory using advanced technology
Eliminates the need to harvest cells from patients or donors, which can be an invasive and painful procedure
Mesenchymal stem cells:
A specific type of perinatal cell with high healing potential
Based on research by Dr. Arthur Caplan and other noted scientists, Wharton’s jelly mesenchymal stem cells (WJ-MSC) derived from umbilical cords share characteristics that can lead to effective treatment and are ethically sourced. These include:
A capacity to divide many times, yet remain undifferentiated
Natural synthesis and secretion of growth factors that stimulate or activate a patient's own cells in a way that promotes expansion and proliferation
More ability to migrate to tissues that require healing and control of inflammation
Immunomodulation and anti-inflammatory properties to better regulate the immune system and reduce harmful inflammation throughout the body
Signaling properties based on cytokines, chemokines, and trophic factors
Cell therapy using mesenchymal stem cells from umbilical cords represents an exciting frontier in the science of medicine. Although these cells do not replace damaged cells in the body, research shows that these cells communicate with other cells – in a sense, “teach” other cells how to function in a way that can help the body heal itself.
Signature Cells Process:
Advanced research in producing high-quality cells
Although MSCs can offer properties that promote healing, our scientists continue to pioneer innovative protocols for selecting, testing, refining, and purifying these cells before they are cultured and expanded into infusions of cells with the highest possible potency. Our proprietary protocol is based on this process:
Strict donor selection: Although cells are harvested from donated umbilical cords, we carefully screen donors based on strict criteria so that the cells we use come from healthy donors who show no sign of serious disease.
Cell screening: Cells extracted from umbilical cords of healthy donors are then screened for specific proteins and other characteristics that the research community has identified as offering high potential for successful treatment.
Purification and expansion: Cells that pass screening tests are purified and then expanded so that infusions can be prepared that contain millions of high-potency cells, which can be transfused into patients via IV – or intramuscular, intraarticular, intradiscal, or intrathecal injection.
After an infusion of high potency cells, the body uses these cells to promote healing, modulate the immune system, and ease chronic inflammation.
In this video, Dr. Santiago Saldarriaga shows before and after MRI images of BioXcellerator patient Jim Stewart after an infusion of cells, pointing out the regeneration and rehydration of disc tissue as well as an improvement in shape.
Ongoing research and innovation
Initial cell research that began more than 25 years ago has established the safety of stem cell therapy. Ongoing research continues to show that mesenchymal stem cells can be used to treat:
Degenerative disc disease
Joint diseases and other musculoskeletal diseases
Brain and neurological disorders
Wounds and tissue restoration
And many others
A recent review by (Galderisi et al.) identified that between 2015 and 2020, there were 416 clinical studies registered to study mesenchymal stem cells isolated from bone marrow, umbilical cord, and adipose tissue -- to treat multiple diseases. According to the U.S. National Institutes of Health database, 117 of those studies have been completed.
Although there has been a significant increase in the number of studies to demonstrate safety and effectiveness, further studies are still needed to confirm this evidence, validate safety and identify future research opportunities in protocols for isolating cells, culturing and expanding cells, and administering them to patients for treatment.
BioXcellerator is now participating in clinical studies that will contribute to this research so that this promising science can help benefit more patients worldwide.
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